Pool 1 – Connacht v Pontypridd (Sunday, 2pm)
Pontypridd put last season's agonising semi-final defeat to Leinster A behind them with a win over London Scottish on the opening weekend. Connacht shipped a half-century of points away to Bristol. Connacht have beaten Welsh opposition twice in six attempts in the B&I Cup, with victories over Cross Keys and Llanelli in 2012 and 2013 respectively. They have never played Pontypridd before though.
Prediction: Pontypridd by 15 points
Pool 2 - Rotherham Titans v Aberavon (Saturday, 3pm)
Tries from Alex Rieder and Jack Preece saw Rotherham open this year's competition with a 20-3 win against Yorkshire Carnegie in Scarborough, while a brace of tries from Wales U20s No.8 Robert Dudley-Jones helped Aberavon pulled off a shock 18-14 win over Ulster's second string. Rotherham won both at home and away when they played Aberavon in the 2012/13 edition of the B&I Cup. After a narrow four-point victory in Port Talbot, the Titans turned on the style to win 49-7 in the return match at Clifton Lane.
Prediction: Rotherham by 10 points
Pool 4 – Bedford Blues v Cross Keys (Saturday, 3pm)
Both Bedford and Cross Keys, two former finalists, began their campaigns with defeats. Blues' on-loan fly half Steffan Jones will know all there is to know about Cross Keys having turned out for the Welsh Premiership side on a number of occasions in recent years. Jones arrived from Newport Gwent Dragons in the summer and wore the number 10 jersey in the opening round loss against the Pirates.
Prediction: Bedford Blues by 2 points
Pool 5 – Carmarthen Quins v Plymouth Albion (Saturday, 2.30pm)
Welsh Premiership high-flyers Carmarthen Quins suffered their first defeat of the season when they were beaten 37-17 by Jersey in Round 1. Quins trailed 17-0 at the break before restoring some pride with a strong second-half showing. Plymouth also showed real character in going down to a 31-24 home defeat to Leinster A, outscoring the defending champions four tries to three to take two bonus points from the game.
Prediction: Carmarthen Quins by 7 points